1. Begin by washing your face with a gentle cleanser and patting skin dry—do not rub.

2. Wait 20–30 minutes after cleansing to ensure skin is completely dry before applying retinol.

3. Take a pea-sized amount of retinol and apply a thin layer to your face, avoiding the eye area, lips, and corners of the nose. 

4. Start with once or twice a week, then gradually increase frequency to every other night, and eventually nightly as your skin builds tolerance. 

5. Follow with a moisturizer to counteract dryness and support the skin barrier.

6. Use retinol only at night to align with the skin’s natural renewal cycle and reduce sun sensitivity. 

7. During the day, always apply and reapply broad-spectrum sunscreen, as retinol increases UV sensitivity.

8. If irritation occurs (redness, peeling, dryness), reduce frequency and focus on hydration.

9. Be consistent—visible improvements in texture, tone, and wrinkles typically take 6-8 weeks.

Avoid combining retinol with other active ingredients like vitamin C, AHAs, BHAs, or benzoyl peroxide unless advised by a dermatologist.

Patch test is essential.
If irritation occurs, cease use and consult a physician.
Use only as directed on unbroken skin.

For external use only.
Keep out of reach of children.

Store in a cool, dry place between 5–25°C.

Protect from direct sunlight.

Due to the natural ingredients in the serum, colour may vary over time.

Topical 1% retinol applied for 7 days in individuals over 80 years old reduced MMP (matrix metalloproteinase) expression and boosted collagen synthesis and fibroblast growth.

One-year, double-blind study showing 0.1% stabilized retinol improved crow’s feet fine lines by 44% and mottled pigmentation by 84%, with increased type I procollagen, hyaluronan, and Ki67 expression.

Retinol (0.1%) + glycolic acid (8%) showed greater improvement in photoaged skin than either ingredient alone

The following peer-reviewed publications relate to topical peptide technology and cosmetic ingredient research:

1. Kang, S., et al. “Topical retinol induces epidermal hyperplasia and dermal collagen synthesis with minimal irritation.” Journal of Investigative Dermatology, 105(4), 1995.

2. Fisher, G. J., et al. “Retinol inhibits ultraviolet-induced matrix metalloproteinases and stimulates collagen production in human skin.” Journal of Investigative Dermatology, 106, 1996; 108, 1997.

3. Fluhr, J. W., et al. “Comparative tolerability of retinol and retinoic acid: effects on barrier function and irritation.” British Journal of Dermatology, 141, 1999.

4. Piérard-Franchimont, C., et al. “A controlled trial demonstrating improvement of fine wrinkles with topical retinol.” Dermatology, 196, 1998.

5. Varani, J., et al. “Topical retinol improves collagen synthesis and reduces matrix metalloproteinase expression in aged human skin.” Journal of Investigative Dermatology, 114, 2000.

6. Kafi, R., et al. “Improvement of naturally aged skin with topical retinol: a randomized, double-blind study.” Archives of Dermatology, 143(5), 2007.

7. Bellemère, G., et al. “Efficacy of stabilized retinol on periocular wrinkles: a whole-face clinical study.” Journal of Cosmetic Dermatology, 8, 2009.

8. Randhawa, M., et al. “Long-term efficacy and tolerability of stabilized retinol in the treatment of facial aging.” Journal of Cosmetic Dermatology, 14, 2015.

9. Tucker-Samaras, S., et al. “Split-face clinical evaluation of stabilized retinol on multiple skin aging parameters.” Journal of Drugs in Dermatology, 16, 2017.

10. Ogawa, M., et al. “One-year double-blind study of stabilized retinol demonstrating significant improvement in fine lines, pigmentation, and dermal biomarkers.” Journal of Cosmetic Dermatology, 2024.